TMG – Trimethylglycine - Longevity Ingredients

Introduction

The donor of methyl groups

Trimethylglycine, or betaine, is a natural molecule that donates “methyl groups” to several reactions of the organism, contributing to keeping homocysteine under control, a parameter frequently associated with cardiovascular wellbeing.

This methylation process is also central to the regulation of the expression of our genes over time, a key theme in longevity research. It is a simple ingredient, but with a role of deep support to general metabolic balance.

What is TMG

Trimethylglycine is present in beetroot – from which the name betaine derives – as well as in spinach, quinoa and wheat germ.

Its function is straightforward but strategic: it makes methyl groups available to the reactions of the methionine cycle, one of the fundamental metabolic hubs of the cell.

Role in Longevity and Healthy Aging

TMG donates methyl groups in the methionine cycle, supporting DNA methylation and the control of homocysteine.

DNA methylation is the mechanism at the basis of the epigenetic clocks used to estimate biological age. Supporting the availability of methyl groups is therefore of direct interest to longevity formulations, particularly those built around NAD+ precursors, which consume them.

Nutraceutical Applications

TMG is formulated in capsules or powder, and is frequently paired with NAD+ precursors in complete longevity formulations.

It balances the consumption of methyl groups induced by NR and NMN, and is synergistic with folic acid and vitamin B12 within the same metabolic cycle.

Naturally Found In

Beetroot (source of the name betaine)
Spinach
Quinoa
Wheat germ

Synergies

NR / NMN – Balances the consumption of methyl groups they induce
Folic acid – Complementary action in the methylation cycle
Vitamin B12 – Cofactor of the methionine cycle