Spermidine is a natural molecule, particularly concentrated in wheat germ, that stimulates autophagy: the process through which cells “clean up” damaged or aged components.
This natural mechanism tends to slow down with age, which is why spermidine is considered one of the most promising ingredients in research on cellular longevity, with a role in supporting the renewal and vitality of cells over time.
Spermidine is a polyamine present in all living cells. In food it is concentrated in wheat germ, and it is also found in fermented soy (natto), aged cheeses and mushrooms.
For nutraceutical use it is generally supplied as a standardized wheat germ extract, which allows the actual spermidine content of each dose to be declared.
Spermidine induces autophagy by inhibiting the acetyltransferase EP300, promoting the natural turnover of damaged cellular components.
Autophagy is one of the mechanisms most closely associated with healthy aging: when it slows down, dysfunctional structures accumulate inside cells and progressively compromise their function.
Spermidine is formulated as a standardized extract in capsules, in supplements positioned around autophagy, often intended for evening intake or during fasting.
It combines well with Resveratrol and NMN, pairing autophagy with mitochondrial function, and it is associated with Fisetin in more complete cellular protocols.
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