Fisetin is a natural flavonoid, present for example in strawberries, that has attracted great attention in longevity research for its role in promoting the selective elimination of senescent cells – those “aged” cells that accumulate in tissues over time and compromise their function.
It is among the most discussed ingredients in the scientific field of “senolysis”, proposed as support to the natural turnover and rejuvenation of cells.
Fisetin is a flavonoid present in strawberries, apples, persimmons and onions, with particularly high concentrations in strawberries.
First identified for its antioxidant potential, it has since been studied for its ability to influence the cellular signalling pathways connected with inflammation, apoptosis and aging.
Fisetin promotes the selective elimination of senescent cells (senolysis) acting on the PI3K/AKT and Bcl-2 pathways.
Senescent cells no longer divide but remain metabolically active, releasing signals that fuel chronic low-grade inflammation (inflammaging). Removing them selectively is one of the most actively investigated approaches in current longevity research.
Fisetin is formulated in capsules, either for continuous intake at low dosage or for high-dosage “pulsed” protocols.
It is frequently combined with quercetin in experimental senolytic protocols, and it is synergistic with spermidine, which pairs autophagy with senolysis. Its low solubility limits absorption, which has prompted the development of liposomal and phytosome forms.
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