Akkermansia muciniphila

Introduction

The guardian of the intestinal barrier

Akkermansia muciniphila is a bacterium naturally present in our intestine, whose abundance tends to decrease physiologically with age. It plays a precious role in keeping the intestinal barrier healthy and intact, a factor increasingly recognized as central to the general balance of the organism.

In the longevity field it is among the most promising postbiotic ingredients, proposed for support to the microbiota and to the wellbeing of the gut-organism axis over time.

What is Akkermansia muciniphila

Akkermansia muciniphila is a commensal bacterium naturally present in the human intestinal mucosa, where it lives in close contact with the mucus layer that protects the intestinal wall.

For nutraceutical use the pasteurized (postbiotic) form is employed: the bacterium is no longer viable, but retains the components responsible for its activity, with clear advantages in terms of stability and standardization.

Role in Longevity and Healthy Aging

Akkermansia muciniphila reinforces the integrity of the intestinal barrier, reducing the translocation of endotoxins that fuel systemic inflammaging.

A permeable intestinal barrier allows bacterial components to pass into the circulation, keeping the immune system in a state of continuous low-intensity activation. This is one of the mechanisms that connects intestinal health with the pace of biological aging.

Nutraceutical Applications

It is formulated in gastro-resistant capsules and belongs to the postbiotic segment, one of the fastest growing areas of the microbiota-longevity market.

It is synergistic with prebiotic fibres such as inulin and with pomegranate polyphenols, which favour its endogenous growth.

Naturally Found In

Natural commensal bacterium of the human intestinal mucosa
For nutraceutical use: pasteurized (postbiotic) form

Synergies